| Abstract [eng] |
Objective To determine risk factors for postoperative intracranial haemorrhage (PIH) after neurosurgical procedures. Patients and methods During November � F�������������������������������������������������������������������������������������������� 2007– February ����������������������������������������������������������������������������������������performed. The collected data were patient’s age, sex, diagnosis, operation, surgeon, preoperative and postoperative ( <12 h and >12 h after surgery) coagulation tests (PLT, APTT, SPA, INR, fibrinogen level). For all patients, postoperative computer tomography was performed to evaluate intracranial haemorrhage. Results The study included male (60.2%, n = 385) and female (39.8%, n = 255) patients. Their mean age was 53.5 ± 16.3 years. PIH occurred following 32 (3.9%) of 802 intracranial procedures. The most frequent diagnosis leading to PIH was acute subdural hematoma evacuation (37.5% of all postoperative intracranial haemorrhages), followed by brain tumour surgery (21.9%). In groups of isolated preoperative hemostasis change: thrombocytopenia <100×109/l (n = 12), APTT >40 s (n = 26), SPA<70%, INR>1.2 (n = 49), hypofibrinogenemy <2 g/l (n = 5) there was no PIH. In the complex hemostasis change group (thrombocytopenia <100×109/l with APTT > 40 s, or SPA < 70%, INR > 1.2, or fibrinogen concentration <2 g/l) 2 patients had PIH. In the non-hematoma group, the mean platelet count was 70×109/l, in the hematoma group 45×109/l (mean diffrence 25×109, 95% PI [10–41], p<0.01), other coagulation parameters did not differ significantly. In the age group <60 years, the rate of postoperative hematoma was 2.1%, in the group >60 years 7.4%, p < 0.01, RR 3.5, 95% PI [1.7–7.3]. Conclusions Isolated thrombocytopenia (60–100×109/l ) does not increase the risk of PIH development. The correction of isolated coagulopathy to APTT 50 s, SPA 52%, INR 1.4, fibrinogen level 1.5 g/l is enought before the neurosurgical procedure. Patients aged >60 years are at 3.5-fold higher risk of postoperative hematoma. |
