| Title |
Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins / |
| Authors |
Denkovskienė, Erna ; Paškevičius, Šarūnas ; Misiūnas, Audrius ; Stočkūnaitė, Benita ; Starkevič, Urtė ; Vitkauskienė, Astra ; Hahn-Löbmann, Simone ; Schulz, Steve ; Giritch, Anatoli ; Gleba, Yuri ; Ražanskienė, Aušra |
| DOI |
10.1038/s41598-019-51969-1 |
| Full Text |
|
| Is Part of |
Scientific reports.. London : Nature Publishing Group. 2019, vol. 9, no. 1, 15422, p. 1-11.. ISSN 2045-2322 |
| Abstract [eng] |
Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escherichia, Pseudomonas and Salmonella. This study is the first report describing pore-forming and peptidoglycan-degrading bacteriocins klebicins from Klebsiella. We have identified, cloned, expressed in plants and characterized nine pore-forming and peptidoglycan-degrading bacteriocins from different Klebsiella species. We demonstrate that klebicins can be used for broad and efficient control of 101 of the 107 clinical isolates representing five Klebsiella species, including multi-drug resistant pathovars and pathovars resistant to carbapenem antibiotics. |
| Published |
London : Nature Publishing Group |
| Type |
Journal article |
| Language |
English |
| Publication date |
2019 |
