| Title |
Imuninė stebėsena širdies transplantacijoje: atmetimo reakcijos poveikis T limfocitų žymenų ekspresijai / |
| Translation of Title |
Measuring T cell reactivity for predicting heart transplant rejection. |
| Authors |
Malickaitė, Radvilė ; Jurgauskienė, Laimutė-Genovaitė ; Simanavičienė, Stanislava ; Maneikienė, Vytė ; Sudikienė, Rita ; Ručinskas, Kęstutis |
| DOI |
10.15388/LietChirur.2010.3.2103 |
| Full Text |
|
| Is Part of |
Lietuvos chirurgija.. Vilnius : Lietuvos chirurgų asociacija. 2010, t. 8, nr. 3, p. 120-126.. ISSN 1392-0995 |
| Keywords [eng] |
Heart transplantation ; Acute rejection ; Immune activation |
| Abstract [eng] |
Objective. We aimed to analyze alterations in peripheral blood T-cell subset activation compared with endomyocardial byopsy findings. Patients and methods. The study included in total twenty-one heart recipients grafted 1997–2007 at the Vilnius HeartsSurgery Center. T-cell activation markers CD3+CD103+, CD4+CD103+, CD8+CD103+, CD3+CD134+, CD4+CD134+, CD8+CD134+, CD8+CD57+ and CD8+CD38+were detected by two-color flow cytometry. Rejection was graded according to the ISHLT (the International Society of Heart and Lung Transplantation) grading system. Results. In case of ≥ 2R (3A) rejection episodes, a significant increase in the expression of integrin CD103 (p < 0.0001), co-stimulatory receptor CD134 (p = 0.005), antigen CD57 (p = 0.005) and surface glycoprotein CD38 (p = 0.015) on CD8+ T lymphocytes has been revealed. Conclusion. Immune monitoring performed on peripheral blood can be used for the assessment of immunosuppression therapy on transplant recipients’ immune response and for determining the risk of rejection. |
| Published |
Vilnius : Lietuvos chirurgų asociacija |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2010 |
| CC license |
|
