Title Human papillomavirus and other risk factors in Lithuanian cervical carcinoma patients /
Translation of Title Žmogaus papilomos viruso paplitimas ir kiti rizikos veiksniai tarp Lietuvos moterų, sergančių gimdos kaklelio vėžiu.
Authors Gudlevičienė, Živilė ; Smilgevičiūtė-Ivshin, Alė ; Vaitkuvienė, Aurelija ; Šepetienė, Agnė ; Didžiapetrienė, Janina
DOI 10.15388/amed.2010.21683
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Is Part of Acta medica Lituanica.. Vilnius : Lietuvos mokslų akademija. 2010, vol. 17, no. 3-4, p. 106-115.. ISSN 1392-0138
Keywords [eng] HPV ; cervical cancer ; risk factors
Abstract [eng] Background. Cervical cancer is the second biggest cause of female cancer mortality world-wide and the most common cancer in women in Lithuania. The incidence of cervical cancer is strongly associated with prevalence of HPV. However, not only HPV infection plays a crucial role in cervical cancer development; other risk factors are important which vary in different populations and geographical regions as well as HPV prevalence. The aim of this study was to detect the HPV; its types prevalence and other cervical cancer risk factors for Lithuanian women. Materials and methods. 191 women with primary diagnosed invasive cervical cancer (cases group) and 397 control women were invited to participate in the study. All women were interviewed and samples for HPV testing were taken. Results. In cases group 92.7% of women were infected by HPV, in control group - 26.7% (p < 0.0001). HPV 16 was the most common type in both groups. HPV infection increases the cervical cancer risk 75 times (OR = 75.39; 95% CI 33.61-192.98). Women with lower education, workers, those who started sexual intercourse before 20 years of age, older age of first menstrual period, 3-5 times or more childbirth, smokers and long time or have never had the PAP test had significantly higher risk for cervical cancer development. Other non HPV risk factors were not associated with cervical cancer risk. Conclusions. Data of our study shows the big prevalence of HPV in Lithuanian population. lt may have all impact to biggest cervical cancer incidence. Other risk factors are similar as in other lower economica! resource countries.
Published Vilnius : Lietuvos mokslų akademija
Type Journal article
Language English
Publication date 2010
CC license CC license description