| Title |
Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays / |
| Authors |
Laurinavičienė, Aida ; Dasevičius, Darius ; Ostapenko, Valerijus ; Jarmalaitė, Sonata ; Lazutka, Juozas Rimantas ; Laurinavičius, Arvydas |
| DOI |
10.1186/1746-1596-6-87 |
| Full Text |
|
| Is Part of |
Diagnostic pathology.. London : BioMed Central. 2011, vol. 6, Art. no 87[p. 1-10].. ISSN 1746-1596 |
| Keywords [eng] |
Quantitative analysis ; Chromosome-17 ; Expression ; Carcinomas ; Reproducibility ; Pathology ; Polysomy |
| Abstract [eng] |
The DA continuous variable of the membrane connectivity correlated with the FISH data (HER2 and CEP17 copy numbers, and HER2/CEP17 ratio). Conclusion: HER2 IHC digital image analysis based on membrane connectivity estimate was in almost perfect agreement with the visual evaluation of the pathologist and more accurate in detection of HER2 FISH-positive patients. Most immediate benefit of integrating the DA algorithm into the routine pathology HER2 testing may be obtained by alerting/reassuring pathologists of potentially misinterpreted IHC 0/1+ versus 2+ cases. |
| Published |
London : BioMed Central |
| Type |
Journal article |
| Language |
English |
| Publication date |
2011 |
