| Title |
The study of NADPH-dependent flavoenzyme-catalyzed reduction of benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans) / |
| Authors |
Šarlauskas, Jonas ; Misevičienė, Lina ; Marozienė, Audronė ; Karvelis, Laimonas ; Stankevičiūtė, Jonita ; Krikštopaitis, Kastis ; Čėnas, Narimantas ; Yantsevich, Alexy V ; Laurynėnas, Audrius ; Anusevičius, Žilvinas |
| DOI |
10.3390/ijms151223307 |
| Full Text |
|
| Is Part of |
International journal of molecular sciences.. Basel : MDPI AG. 2014, Vol. 15, iss. 12, p. 23307-23331.. ISSN 1422-0067 |
| Keywords [eng] |
Benzofuroxan ; Flavoenzyme ; Redox-cycling ; Bioreductive conversion ; Quantitative structure activity relationship ; Quantum mechanical calculation ; DFT |
| Abstract [eng] |
The reductive conversion of benzofuroxan by both flavoenzymes yielded the same reduction product of benzofuroxan, 2,3-diaminophenazine, with the formation of o-benzoquinone dioxime as a putative primary reductive intermediate, which undergoes a further reduction process. Overall, the data obtained show that by contrast to NACs, the flavoenzyme-catalyzed reduction of BFXs is unlikely to initiate their redox-cycling, which may argue for a minor role of the redox-cycling-type action in the cytotoxicity of BFXs. |
| Published |
Basel : MDPI AG |
| Type |
Journal article |
| Language |
English |
| Publication date |
2014 |
