Title Bioavailability of different vitamin D oral supplements in laboratory animal model /
Authors Šimoliūnas, Egidijus ; Rinkūnaitė, Ieva ; Bukelskienė, Živilė ; Bukelskienė, Virginija
DOI 10.3390/medicina55060265
Full Text Download
Is Part of Medicina / Lithuanian University of Health Sciences.. Basel : MDPI. 2019, vol. 55, iss. 6, art. no. 265, p. [1-8].. ISSN 1010-660X. eISSN 1648-9144
Keywords [eng] vitamin D ; oral supplements ; vehicle ; bioavailability ; vitamin D deficiency
Abstract [eng] Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based. Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D-3, the second-oil-based vitamin D-3, and the third-micellized vitamin D-3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day. Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D-3 vehicles were the most bioavailable in comparison to micellized vitamin D-3. Even more, the effect of the microencapsulated form of vitamin D-3 remained constant for the longest period (up to 14 days). Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2019