| Title |
Early radiation-induced sarcoma in an adolescent treated for relapsed Hodgkin lymphoma with Nivolumab / |
| Authors |
Šalaševičius, Lukas ; Vaitkevičienė, Goda Elizabeta ; Pasaulienė, Ramunė ; Kiudelienė, Rosita ; Ivanauskaitė-Didžiokienė, Ernesta ; Vajauskas, Donatas ; Jurkienė, Nemira ; Rascon, Jelena |
| DOI |
10.3390/medicina56040155 |
| Full Text |
|
| Is Part of |
Medicina.. Kaunas ; Basel : LSMU ; MDPI. 2020, vol. 56, no. 4, art. no. 155, p. 1-7.. ISSN 1010-660X. eISSN 1648-9144 |
| Keywords [eng] |
Hodgkin lymphoma ; Post-radiation sarcoma ; Nivolumab ; Children ; Obesity |
| Abstract [eng] |
Radiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment. |
| Published |
Kaunas ; Basel : LSMU ; MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
