| Title |
Treatment of experimental amyloidosis with antirheumatic drugs |
| Translation of Title |
Eksperimentinės amiloidozės gydymas priešreumatiniais vaistais. |
| Authors |
Leonavičienė, Laima ; Povilėnaitė, Danutė ; Bradūnaitė, Rūta ; Vaitkienė, Dalia ; Venalis, Algirdas |
| DOI |
10.15388/amed.2010.21688 |
| Full Text |
|
| Is Part of |
Acta medica Lituanica.. Vilnius. 2010, Vol. 17, no. 1-2, p. 17-29.. ISSN 1392-0138 |
| Keywords [eng] |
Mice ; Experimental AA amyloidosis ; Antirheumatic drugs |
| Abstract [eng] |
Treatment of mice with D alone produced a signifi cant reduction in amyloid deposition only in the liver (p < 0.03) and with SSL only in the spleen (p < 0.03). Conclusions. These fi ndings suggest that D/P and SSL at relevant doses suppress amyloidogenesis, and this suppression is possibly related to the anti-infl ammatory eff ect of antirheumatic drugs. Although these drugs cannot completely inhibit the disease in this model, a possibility remains that they may be clinically useful in rheumatic diseases associated with the formation of amyloidogenic derivatives. |
| Published |
Vilnius |
| Type |
Journal article |
| Language |
English |
| Publication date |
2010 |
| CC license |
|
