Title The status of antioxidative system in pregnant women infected with human papilloma virus /
Translation of Title ŽIV infekuotų nėščiųjų antioksidacinės sistemos būklė.
Authors Surinėnaitė, Birutė ; Domža, Gintautas ; Didžiapetrienė, Janina ; Prasmickienė, Gražina ; Gudlevičienė, Živilė ; Jakaitienė, Audronė
DOI 10.15388/amed.2010.21680
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Is Part of Acta medica Lituanica. 2010, Vol. 17, no. 3-4, p. 83-92.. ISSN 1392-0138
Keywords [eng] HPV infection ; Pregnancy ; Antioxidative system
Abstract [eng] All pregnant women were compared with non-pregnant women to confirm the influence of pregnancy on the MDA level. In the first trimester, this parameter for pregnant women was close to that of non-pregnant women, while with the developing pregnancy the MDA level increased 1.6 times. No significant difference in the parameter was determined for pregnant women with HPV infection. Conclusions. A decrease of GSH concentration and an increase of MDA level in blood plasma with the development of pregnancy confirmed the presence of a general oxidative stress. The lower levels of GSH and GSH + GSSG in the cervicovaginal washing fluid, if to compare the two trimesters of pregnancy, can be considered as markers of a local oxidative stress. HPV infection depressed the antioxidative system in general and did not affect it at the local level. Systemic oxidative stress, rather than HPV infection, influenced the lipid peroxidation process during pregnancy. The level of MDA is recommended to be tested also during a normal pregnancy, although this parameter should not be considered as an additional biomarker of cervical carcinoma risk. Changes of the antioxidative system variables could induce a deep oxidative imbalance during a pathological pregnancy, and oxidative stress might cause a persistent HPV infection, suggesting the importance of the additional screening of HPV-infected women after delivery.
Type Journal article
Language English
Publication date 2010
CC license CC license description