| Title |
Gastrointestininės stromos navikai: dabartinis požiūris ir diagnostika / |
| Translation of Title |
Gastrointestinal stromal tumors: the present attitude and diagnostics. |
| Authors |
Plečkaitis, Mindaugas ; Mickys, Ugnius ; Rimkevičius, Arvydas |
| DOI |
10.15388/LietChirur.2005.3.2308 |
| Full Text |
|
| Is Part of |
Lietuvos chirurgija.. Vilnius : Vilniaus universiteto leidykla. 2005, t. 3, Nr. 3, p. 176-183.. ISSN 1392-0995. eISSN 1648-9942 |
| Keywords [eng] |
gastrointestinal stromal tumors ; c-kit proto-oncogene ; CD117 |
| Abstract [eng] |
Traditionally, spindle cell tumors of the gastrointestinal tract have been classified as leiomyoma or leiomyosarcoma because of a close morphologic resemblance to smooth muscle tumors. Tumors with epithelioid cells were designated as leiomyoblastoma and later as epithelioid leiomyoma or leiomyosarcoma. The term “gastrointestinal stromal tumor” included smooth muscle tumors, neural tumors and undiferentiated tumors. The discovery of CD117 hyperexpression gave the possibility to separate the GIST group, which is different from smooth muscle and neural tumors of gastrintestinal tract. The majority of GISTs (approximately 95%) are related to mutations of the c-kit proto-oncogene gene. These mutations result in a hyperexpression of the transmembrane growth factor receptor (CD117 protein / c-kit), which is reliably detected by immunohistochemistry. The present attitude of hystogenesis, epidemiology, pathology, immunofenotype, differential diagnosis, treatment, some methodologic aspects of diagnostics and schemes of biological behavior of gastrointestinal stromal tumors are summarized in the review. |
| Published |
Vilnius : Vilniaus universiteto leidykla |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2005 |
| CC license |
|
