Title |
Beneficial neurohumoral profile in left ventricular systolic dysfunction following acute myocardial infarction / |
Authors |
Balčiūnaitė, Giedrė ; Rudys, Alfredas ; Bičkauskaitė, Neli ; Zakarkaitė, Diana ; Skorniakov, Viktor ; Čelutkienė, Jelena ; Laucevičius, Aleksandras |
DOI |
10.2478/s11536-012-0141-6 |
Full Text |
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Is Part of |
Central European journal of medicine.. Warsaw : Versita. 2014, vol. 9, no. 1, p. 64-73.. ISSN 1895-1058 |
Keywords [eng] |
Heart failure ; Left ventricular systolic dysfunction ; Renin-angiotensin-aldosterone system ; NT-proBNP ; Eplerenone |
Abstract [eng] |
Logistic regression models for prediction of significant left ventricular ejection fraction improvement (LVEF after 6 months- LVEF at baseline ≥5%) did not demonstrate that renal function measurements are suitable for this purpose. Conclusions. A combined heart failure regimen, including aldosterone inhibitor eplerenone, in patients with left ventricular systolic dysfunction following acute MI decreases circulating levels of natriuretic peptides and renin and increases levels of aldosterone. The reduction in NT-proBNP is related to improvement of left ventricular systolic function and possibly to improved LV compliance and reduction of LV-filling pressures, whereas the increase in aldosterone levels could reflect activated feedback mechanisms of RAAS. A mild reduction in eGFR can be expected in the course of HF therapy in post-MI patients with normal baseline renal function. A severe hyperkalemia can be prevented by close monitoring of renal function and potassium levels. Our findings suggest, that there is a direct linear relationship between renal function and markers of myocardial function early post-MI, which is no longer present after six months. Cardio-renal correlation is best reflected by raw values of creatinine. |
Published |
Warsaw : Versita |
Type |
Journal article |
Language |
English |
Publication date |
2014 |