| Title |
Insights into the CRISPR/Cas system of Gardnerella vaginalis / |
| Authors |
Plečkaitytė, Milda ; Zilnytė, Milda ; Žvirblienė, Aurelija |
| DOI |
10.1186/1471-2180-12-301 |
| Full Text |
|
| Is Part of |
BMC microbiology.. London : BioMed Central Ltd. 2012, vol. 12, Art. no 301 [p. 1-11].. ISSN 1471-2180 |
| Abstract [eng] |
Gardnerella vaginalis is identified as the predominant colonist of the vaginal tracts of women diagnosed with bacterial vaginosis (BV). G. vaginalis can be isolated from healthy women, and an asymptomatic BV state is also recognised. The association of G. vaginalis with different clinical phenotypes could be explained by different cytotoxicity of the strains, presumably based on disparate gene content. The contribution of horizontal gene transfer to shaping the genomes of G. vaginalis is acknowledged. The CRISPR loci of the recently discovered CRISPR/Cas microbial defence system provide a historical view of the exposure of prokaryotes to a variety of foreign genetic elements. |
| Published |
London : BioMed Central Ltd |
| Type |
Journal article |
| Language |
English |
| Publication date |
2012 |
