| Title |
Enteropathies and oxidative stress / |
| Translation of Title |
Enteropatijos ir oksidacinis stresas. |
| Authors |
Glemžienė, Ina ; Kazėnaitė, Edita ; Kalibatienė, Danutė ; Lukšienė, Aloyza |
| Full Text |
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| Is Part of |
Acta medica Lituanica. 2006, vol. 13, no. 4, p. 232-235.. ISSN 1392-0138 |
| Keywords [eng] |
Glutenic enteropathy ; Hypolactasia ; Rheumatoid arthritis ; Oxidative stress ; Lipid peroxidation |
| Abstract [eng] |
Background: Oxidative stress is related with digestive tract diseases – pancreatitis, duodenal ulcer, ulcerative colitis, glutenic enteropathy. Changes in the antioxidation system can be conditioned by malabsorbtion. The aim of the work was to evaluate the alterations in peroxidationantioxidation status indexes in cases of glutenic enteropathy associated with hypolactasia and with rheumatoid arthritis, to compare data received while examining patients and members of the control group. Materials and methods: Peroxidative status was evaluated according to malondialdehyde (MDA) concentration in the blood serum in 64 subjects, among them 11 had glutenic enteropathy associated with hypolactasia, 23 – with rheumatoid arthritis, and 30 subjects (with digestive system diseases in remission phase) were from the control group. Antioxidation system status was analyzed by measuring catalase activity. Results: It was established that in case of glutenic enteropathy associated with hypolactasia malondialdehyde concentration increased 1.5 times: 5.93 ± 0.31 versus 3.34 ± 0.12 (p < 0.001) in the control group; the concentration of diyenic conjugate increased 1.7 times 9.24 ± 0.74 versus the control group (5.6 ± 1.9, p < 0.001). Catalase activity decreased from 42.34 ± 2.2 in the control group to 28.71 ± 2.1 in glutenic enteropathy hypolactasia patients, i. e. 1.3 times (p < 0.05). For enteropathy glutenic patients with rheumatoid arthritis the following lipid peroxidation markers were established: concentration of malondialdehyde increased 1.5 times (5.67 ± 0.23) versus the control group (3.48 ± 0.11, p < 0.001); diyenic conjugates concentration increased 1.6 times (9.90 ± 0.66) versus 5.8 ± 1.9 (p < 0.001) in the control group. Catalase activity decreased from 42.96 ± 2.1 in the control group to 29.25 ± 1.8 in glutenic enteropathy patients with rheumatoid arthritis, i. e. 1.3 times (p < 0.05)... |
| Type |
Journal article |
| Language |
English |
| Publication date |
2006 |
