Title Body mass index, cholesterol level and risk of lung cancer in Lithuanian men /
Authors Everatt, Rūta ; Virvičiūtė, Dalia ; Kuzmickienė, Irena ; Tamošiūnas, Abdonas
DOI 10.1016/j.lungcan.2014.07.009
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Is Part of Lung cancer.. Amsterdam : Elsevier. 2014, vol. 85, iss. 3, p. 361-365.. ISSN 0169-5002
Keywords [eng] Lung neoplasms ; Risk factors ; Body mass index ; Cholesterol ; Men ; Cohort studies ; Lithuania
Abstract [eng] Objective: Our objective was to investigate the association between body mass index (BMI), total serumcholesterol (TSC) level and risk of lung cancer in a Lithuanian population-based cohort study.Materials and methods: The study included 6729 men initially free from cancer. During the follow-up(1978–2008), 358 lung cancer cases were identified. Cox proportional hazards models were used toestimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI).Results: Following adjustment for age, smoking, alcohol consumption, and education, BMI 25–29.9and ≥30.0 kg/m2hazard ratios (HR) were significantly associated with decreasing risk for lung can-cer, HR = 0.73; 95% CI: 0.59, 0.91 and 0.62; 95% CI: 0.45, 0.87, respectively (ptrend= 0.001) compared toBMI <25 kg/m2. Inverse association between BMI and lung cancer was observed among current smokers.We found no evidence that BMI was associated with decreased lung cancer risk in never smokers, althoughsmall sample size precluded meaningful analysis. Not significantly lower risk of lung cancer among par-ticipants in the 5th quintile compared with the 1st quintile of TSC concentrations was observed. HR per1 mmol/l increase of TSC was 0.90; 95% CI: 0.82, 1.00. Findings suggest consistent effects of BMI and TSCwhen follow-up was 1993–2008.Conclusion: Our results show an inverse dose-dependent association between lung cancer risk and BMIin Lithuanian men, especially among current smokers. The inverse association could not be attributed topreclinical cancer effect hypothesis. TSC level was not statistically significantly related to a lung cancerincidence.
Published Amsterdam : Elsevier
Type Journal article
Language English
Publication date 2014