Title Atherosclerosis: alterations in cell communication /
Translation of Title Aterosklerozė: ląstelių komunikacijų pokyčiai.
Authors Timinskas, Albertas ; Kučinskienė, Zita Aušrelė ; Kučinskas, Vaidutis
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Is Part of Acta medica Lituanica. 2007, Vol. 14, no. 1. ISSN 1392-0138
Keywords [eng] Atherosclerosis ; Linked genes ; Data mining ; Signaling pathways ; Cell communication ; Genomics
Abstract [eng] Objective. We investigated the distribution of atherosclerosis-linked genes within known metabolic / signaling pathways in order to determine most vulnerable pathways during atherosclerosis pathogenesis as well as to compile a full list of genes predominant for the disease. Materials and Methods. A search for genes associated with atherosclerosis within PubMed abstracts was carried out using modern data mining techniques available at SNPs3D database. Presence of data on metabolic pathways for each gene of interest was checked using KEGG and g-language tools. Association of atherosclerosis-linked genes within pathways was visualized and estimated using the g-language tool. Results. Analysis of to-date PubMed abstracts resulted in 748 human genes associated with atherosclerosis. Further analysis has revealed that 134 of over 300 known to date metabolic / signaling pathways include at least one gene associated with atherosclerosis of the total of 436 genes. Reducing accident ascription pathways populated by at least 10 atherosclerosis- linked genes were only taken into account making final conclusions. Conclusions. Taken together, our results demonstrate that the essence of atherosclerosis is the dysfunction of cell signaling and intercell communication cascades. We maintain an exclusively high role of cytokines and their receptors in atherosclerosis pathogenesis. A sufficiently high intersection of atherosclerosis and diabetes or several cancer species proposed an increased risk for further complications in these patients.
Type Journal article
Language English
Publication date 2007