| Abstract [eng] |
Risk factors, such as tobacco use, physical inactivity, harmful use of alcohol, unhealthy diet and an increase in the caloric intake over the past 60–100 years contribute to an intensified generation and accumulation of reactive oxygen species, leading to the development of oxidative stress in the human body. The results of this study suggest that oxidative stress causes an alteration in fatty acids, particularly polyunsaturated fatty acids, which are involved in the synthesis of biologically active compounds (e.g. eicosanoids/docosanides), influencing the pathogenesis of the inflammatory process, thereby directly or indirectly affecting the development and progression of chronic non-communicable diseases, including uronephrolithiasis. |
