| Title |
The role of cardiac T-cadherin in the indicating heart failure severity of patients with non-ischemic dilated cardiomyopathy / |
| Authors |
Baltrūnienė, Vaida ; Rinkūnaitė, Ieva ; Bogomolovas, Julijus ; Bironaitė, Daiva ; Kažukauskienė, Ieva ; Šimoliūnas, Egidijus ; Ručinskas, Kęstutis ; Puronaitė, Roma ; Bukelskienė, Virginija ; Grabauskienė, Virginija |
| DOI |
10.3390/medicina56010027 |
| Full Text |
|
| Is Part of |
Medicina.. Kaunas; Basel : LSMU, MDPI AG. 2020, vol. 56, no. 1, art. no 27, p. [1-14].. ISSN 1010-660X. eISSN 1648-9144 |
| Keywords [eng] |
adiponectin ; advanced heart failure ; non-ischemic dilated cardiomyopathy ; T-cadherin |
| Abstract [eng] |
Background and objectives: T-cadherin (T-cad) is one of the adiponectin receptors abundantly expressed in the heart and blood vessels. Experimental studies show that T-cad sequesters adiponectin in cardiovascular tissues and is critical for adiponectin-mediated cardio-protection. However, there are no data connecting cardiac T-cad levels with human chronic heart failure (HF). The aim of this study was to assess whether myocardial T-cad concentration is associated with chronic HF severity and whether the T-cad levels in human heart tissue might predict outcomes in patients with non-ischemic dilated cardiomyopathy (NI-DCM). Materials and Methods: 29 patients with chronic NI-DCM and advanced HF were enrolled. Patients underwent regular laboratory investigations, echocardiography, coronary angiography, and right heart catheterization. TNF- and IL6 in serum were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, endomyocardial biopsies were obtained, and the levels of T-cad were assessed by ELISA and CD3, CD45Ro, CD68, and CD4- immunohistochemically. Mean pulmonary capillary wedge pressure (PCWP) was used as a marker of HF severity, subdividing patients into two groups: mean PCWP > 19 mmHg vs. mean PCWP < 19 mmHg. Patients were followed-up for 5 years. The study outcome was composite: left ventricular assist device implantation, heart transplantation, or death from cardiovascular causes. Results: T-cad shows an inverse correlation with the mean PCWP (rho = 0.397, p = 0.037). There is a tendency towards a lower T-cad concentration in patients with more severe HF, as indicated by the mean PCWP > 19 mmHg compared to those with mean PCWP 19 mmHg (p = 0.058). Cardiac T-cad levels correlate negatively with myocardial CD3 cell count (rho = 0.423, p = 0.028). Conclusions: Univariate Cox regression analysis did not prove T-cad to be an outcome predictor (HR = 1, p = 0.349). However, decreased T-cad levels in human myocardium can be an additional indicator of HF severity. T-cad in human myocardium has an anti-inflammatory role. More studies are needed to extend the role of T-cad in the outcome prediction of patients with NI-DCM. |
| Published |
Kaunas; Basel : LSMU, MDPI AG |
| Type |
Journal article |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
