| Title |
Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils / |
| Authors |
Musteikytė, Greta ; Žiaunys, Mantas ; Smirnovas, Vytautas |
| DOI |
10.7717/peerj.9719 |
| Full Text |
|
| Is Part of |
PeerJ.. London : PeerJ Inc.. 2020, vol. 8, art. no. e9719, p. [1-17].. ISSN 2167-8359. eISSN 2167-8359 |
| Keywords [eng] |
Amyloid ; Fibril elongation ; Inhibition ; Methylene blue ; Nucleation ; Protein aggregation ; Protein misfolding ; Superoxide dismutase. |
| Abstract [eng] |
Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins. In this work we show its ability to inhibit both the spontaneous amyloid aggregation of SOD1 as well as elongation of preformed fibrils. |
| Published |
London : PeerJ Inc |
| Type |
Journal article |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
