| Title |
Tumor-promoting Ly-6G+ SiglecFhigh cells are mature and long-lived neutrophils / |
| Authors |
Pfirschke, Christina ; Engblom, Camilla ; Gungabeesoon, Jeremy ; Lin, Yunkang ; Rickelt, Steffen ; Žilionis, Rapolas ; Massemaker, Marius ; Siwicki, Marie ; Gerhard, Genevieve M ; Kohl, Anna ; Meylan, Etienne ; Weissleder, Ralph ; Klein, Allon M ; Pittet, Mikael J |
| DOI |
10.1016/j.celrep.2020.108164 |
| Full Text |
|
| Is Part of |
Cell reports.. Cambridge, MA : Cell Press. 2020, vol. 32, no. 12, art. no.108164, p. [1-19].. eISSN 2211-1247 |
| Keywords [eng] |
neutrophils ; cancer ; myeloid cells |
| Abstract [eng] |
Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of these cells’ fundamental features remain unexplored. Here, we show that tumor-infiltrating CD11b+ Ly-6G+ SiglecFhigh cells are bona fide mature neutrophils and therefore differ from other myeloid cells, including SiglecFhigh eosinophils, SiglecFhigh macrophages, and CD11b+ Ly-6G+ myeloid-derived suppressor cells. We further show that SiglecFhigh neutrophils gradually accumulate in growing tumors, where they can live for several days; this lifespan is in marked contrast to that of their SiglecFlow counterparts and neutrophils in general, which live for several hours only. Together, these findings reveal distinct attributes for tumor-promoting SiglecFhigh neutrophils and help explain their deleterious accumulation in the tumor bed. |
| Published |
Cambridge, MA : Cell Press |
| Type |
Journal article |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
