| Title |
Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis / |
| Authors |
Mauliūtė, Monika ; Rugienė, Rita ; Žėkas, Vytautas ; Bagdonaitė, Loreta |
| DOI |
10.1515/labmed-2020-0050 |
| Full Text |
|
| Is Part of |
Journal of laboratory medicine.. Berlin : Walter De Gruyter. 2020, vol. 44, iss. 6, p. 343-3475.. ISSN 2567-9430. eISSN 2567-9449 |
| Keywords [eng] |
endothelin-1 (ET-1) ; intercellular adhesion molecule-1 (ICAM-1) ; systemic sclerosis ; vascular cell adhesion molecule-1 (VCAM-1) |
| Abstract [eng] |
Objectives Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, including systemic sclerosis. In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules–intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).The aim of the study was to evaluate the diagnostic value of the detection of ET-1, VCAM-1 and ICAM-1 in the diagnosis of systemic sclerosis. Methods A total of 30 patients with systemic sclerosis from Vilnius University Hospital Santaros Clinics were included in the study. Serum levels of ICAM-1, VCAM-1 and ET-1 were assessed by enzyme immunoassay. Results ET-1 concentration was associated with VCAM-1 concentration (r=0.687; p<0.001). No associations between ET-1 and ICAM-1 concentrations were detected. Depending on the duration of the disease no significant differences in the concentrations of ET-1, ICAM-1 and VCAM-1 were detected. Conclusions The results of this study indicated that ET-1 and VCAM-1 may be assessed together as markers of inflammation and the identification of patients at high risk for disease progression. |
| Published |
Berlin : Walter De Gruyter |
| Type |
Journal article |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
