| Abstract [eng] |
Ischemic stroke is an acute cerebrovascular disease, which can often cause permanent neurological deficit or death. It is also one of the most common and economically damaging diseases, especially among older people. Mechanical thrombectomy (MTE) is a relatively recent reperfusion therapy method that seeks to restore impaired cerebral circulation by removing thrombi – i.e. the emboli that caused cerebral ischemia – from blocked arteries using special extractors or aspiration catheters. It was only in 2015 (the year in which our study was initiated) that it became an officially recommended treatment method of large-artery occlusion. A lot of additional factors that might affect the clinical outcomes in ischemic stroke patients treated with MTE remain unresearched. Each of the medical centres specialising in ischemic stroke treatment applies its own methodology due to its regional specifics, financial situation, and technical capabilities for both diagnostic analysis and MTE procedures themselves in ischemic stroke patients. Aim of the study is to assess mechanical thrombectomy treatment results and factors affecting them in ischemic stroke patients. Study objectives: 1. To assess the influence of patients’ risk factors, demographic indicators, and functional status on mechanical thrombectomy treatment results. 2. To assess the effect of bridging therapy on clinical outcomes in patients with acute anterior circulation ischemia who were treated using mechanical thrombectomy. 3. To assess factors that may affect the effectiveness of MTE treatment (the time elapsed between the onset of symptoms and the arrival to a medical institution and performance of neuro-visual examination as well as its assessment, and until the start of MTE and recanalization; morphological radiological changes in the cerebrum; clinical characteristics of ischemic stroke; periprocedural factors: the anaesthesia applied, the dose of the intravenous thrombolytic agent, the devices used for the mechanical thrombectomy). 4. To assess both early and late results of this type of treatment and any complications that may arise (functional outcome quantified using the modified Rankin Scale 90 days after the procedure; recanalization rate in the occlusion territory using the TICI scale; dynamics of the neurological condition using the NIH Stroke Scale after 2 hours and 24 hours from MTE; complications). |
