Title Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery /
Authors Kryžauskas, Marius ; Baušys, Augustinas ; Degutytė, Austėja Elžbieta ; Abeciūnas, Vilius ; Poškus, Eligijus ; Baušys, Rimantas ; Dulskas, Audrius ; Strupas, Kęstutis ; Poškus, Tomas
DOI 10.1186/s12957-020-01968-8
Full Text Download
Is Part of World journal of surgical oncology.. London : BioMed Central Ltd. 2020, vol. 18, iss. 1, art. no. 205, p. [1-10].. eISSN 1477-7819
Keywords [eng] Anastomotic leakage ; Colorectal cancer ; Disease-free survival ; Oncological outcomes ; Overall survival ; Risk factors
Abstract [eng] Background: Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods: Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results: AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III-IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score > 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion: ASA score of III-IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery.
Published London : BioMed Central Ltd
Type Journal article
Language English
Publication date 2020
CC license CC license description