| Title |
Derivatives of 3-[(4- methoxyphenyl)amino]propanehydrazide: towards anticancer and antioxidant agents / |
| Authors |
Tumosienė, I ; Petrikaitė, V ; Jonuškienė, I ; Kantminienė, K |
| ISBN |
9786090705575 |
| Full Text |
|
| Is Part of |
NBCM 2020: international conference on nanostructured bioceramic materials, 1-3 December 2020, Vilnius, Vilnius University: conference book.. Vilnius : Vilnius Univerity Press, 2020. p. 43.. ISBN 9786090705575 |
| Keywords [eng] |
1,3,4-thiadiazole ; 1,2,4-triazolin-5-thione ; isoindoline-1,3-dione ; derivatives |
| Abstract [eng] |
Recently, thiadiazole, triazolethione and isatin derivatives have been attracting attention of medicinal chemists as promissing chemical scaffolds with a broad spectrum of activity, low toxicity and excellent pharmacokinetic properties. A series of novel 1,3,4-thiadiazole, 1,2,4-triazolin-5-thione, and isoindoline-1,3-dione derivatives were synthesized from 3-[(4-methoxyphenyl)amino]propanehydrazide and their structures were confirmed by IR, 1H, 13C NMR spectroscopy and mass spectrometry data. Anticancer activity of the synthesized compounds was screened by MTT assay against human glioblastoma U-87 and triplenegative breast cancer MDA-MB-231 cell lines. The tested compounds were more cytotoxic against U-87 cell line than MDA-MB-231 one. 1-(4-Fluorophenyl)-2-((5-(2-((4- methoxyphenyl)amino)ethyl)-4-phenyl-4H-1,2,4-triazol-3- yl)thio)ethanone (12) has been identified as the most active compound against glioblastoma U-87 cell line. It has shown different activity on both cell lines, possibly due to selectivity on specific targets in glioblastoma cells, and, therefore, has been identified as possessing the promising anticancer activity. |
| Published |
Vilnius : Vilnius Univerity Press, 2020 |
| Type |
Conference paper |
| Language |
English |
| Publication date |
2020 |
| CC license |
|
