| Title |
The characteristics of HIV-positive patients with mild/asymptomatic and mpderate/severe course of COVID-19 disease – a report from Central and Eastern Europe / |
| Authors |
Kowalska, Justyna ; Kase, Kerstin ; Vassilenko, Anna ; Harxhi, Arjan ; Lakatos, Botond ; Lukic, Gordana Dragovic ; Verhaz, Antonija ; Yancheva, Nina ; Dumitrescu, Florentina ; Jilich, David ; Machala, Ladislav ; Skrzat-Klapaczynska, Agata ; Matulionytė, Raimonda |
| DOI |
10.1016/j.ijid.2020.12.026 |
| Full Text |
|
| Is Part of |
International journal of infectious diseases.. Oxford : Elsevier Science. 2021, vol. 104, p. 293-296.. ISSN 1201-9712. eISSN 1878-3511 |
| Keywords [eng] |
HIV ; SARS-CoV-2 ; COVID-19 ; antiretroviral therapy ; protease inhibitors |
| Abstract [eng] |
Background There is currently no evidence suggesting that COVID-19 takes a different course in HIV-positive patients on antiretroviral treatment compared to the general population. However, little is known about the relation between specific HIV-related factors and the severity of the COVID-19 disease. Methods We performed a retrospective analysis of cases collected through an on-line survey distributed by the Euroguidelines in Central and Eastern Europe Network Group. In statistical analyses characteristics of HIV-positive patients asymptomatic/moderate and moderate/severe course were compared. Results In total 34 HIV-positive patients diagnosed with COVID-19 were reported by 12 countries (Estonia, Czech Republic, Lithuania, Albania, Belarus, Romania, Serbia, Bosnia and Herzegovina, Poland, Russia, Hungary, Bulgaria). Asymptomatic courses of COVID-19 were reported in four (12%) cases, 11 (32%) patients presented with mild disease not requiring hospitalization, moderate disease with respiratory and/or systemic symptoms was observed in 14 (41%) cases, and severe disease with respiratory failure was found in five (15%) patients. The HIV-related characteristics of patients with asymptomatic/mild course of COVID-19 were comparable to those with moderate/severe course of COVID-19, except for the use of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in cART regimen ( 0.0% vs. 31.6% respectively, p = 0.0239 ). Conclusions In our analyses HIV viral suppression and immunological status were not associated with the course of COVID-19 disease. On the contrary the cART regimen could contribute to severity of SARS-CoV-2 infection. Large and prospective studies are necessary to further investigate this relations. |
| Published |
Oxford : Elsevier Science |
| Type |
Journal article |
| Language |
English |
| Publication date |
2021 |
| CC license |
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