Tenecteplase in wake-up ischemic stroke trial: protocol for a randomized-controlled trial /

Melinda B Roaldsen; Haakon Lindekleiv; Agnethe Eltof; Mirza Jusufovic; Mary-Helen Søyland; Jesper Petersson; Bent Indredavik; Arnstein Tveiten; Jukka Putaala; Hanne Christensen; Janika Korv; Dalius Jatužis; Stefan T Engelter; Gian Marco De Marchis; Tom Wilsgaard; David J Werring; Thompson Robinson; Ellisiv B Mathiesen; Eivind Bergenr

doi:10.1177/1747493020984073

Title	Tenecteplase in wake-up ischemic stroke trial: protocol for a randomized-controlled trial /
Authors	Roaldsen, Melinda B ; Lindekleiv, Haakon ; Eltof, Agnethe ; Jusufovic, Mirza ; Søyland, Mary-Helen ; Petersson, Jesper ; Indredavik, Bent ; Tveiten, Arnstein ; Putaala, Jukka ; Christensen, Hanne ; Korv, Janika ; Jatužis, Dalius ; Engelter, Stefan T ; De Marchis, Gian Marco ; Wilsgaard, Tom ; Werring, David J ; Robinson, Thompson ; Mathiesen, Ellisiv B ; Bergenr, Eivind
DOI	10.1177/1747493020984073
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Is Part of	International journal of stroke.. London : SAGE. 2021, vol. 16, no. 8, p. 990-994.. ISSN 1747-4930. eISSN 1747-4949
Keywords [eng]	TWIST ; Tenecteplase ; acute ischemic stroke ; intravenous thrombolysis ; wake-up stroke.
Abstract [eng]	Background: Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with acute ischemic stroke. The aim of the Tenecteplase in Wake-up Ischemic Stroke Trial (TWIST) is to compare the effect of thrombolytic treatment with tenecteplase and standard care versus standard care alone in patients with wake-up ischemic stroke selected by non-contrast CT. Methods/design: TWIST is an international, investigator-initiated, multi-centre, prospective, randomized-controlled, open-label, blinded end-point trial of tenecteplase (n = 300) versus standard care (n = 300) in patients who wake up with an acute ischemic stroke and can be treated within 4.5 h upon awakening. Seventy-seven centres in 10 countries (Denmark, Estonia, Finland, Latvia, Lithuania, New Zealand, Norway, Sweden, Switzerland, and the United Kingdom) participate. The primary outcome is the modified Rankin Scale on the ordinal scale (0-6) at three months. Discussion: TWIST aims to determine the effect and safety of thrombolytic treatment with tenecteplase in patients with wake-up ischemic stroke selected by non-contrast CT.
Published	London : SAGE
Type	Journal article
Language	English
Publication date	2021
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„Tenecteplase in wake-up ischemic stroke trial: protocol for a randomized-controlled trial /“