Title New 1-(3-nitrophenyl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3- a][1,5]benzodiazepines: synthesis and computational study /
Authors Kosychova, Lidija ; Karalius, Antanas ; Staniulytė, Zita ; Sirutkaitis, Romualdas Aleksas ; Palaima, Algirdas ; Laurynėnas, Audrius ; Anusevičius, Žilvinas
DOI 10.3390/molecules20045392
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Is Part of Molecules.. Basel : MDPI. 2015, vol. 20, no. 4, p. 5392-5408.. eISSN 1420-3049
Keywords [eng] [1,2,4]triazolo[4,3-a][1,5]-benzodiazepine ; 3-nitrobenzohydrazide ; five-membered fused heterocycles ; quantum mechanical calculation ; density functional theory (DFT) ; DFT global descriptors ; DFT local descriptors ; Fukui index
Abstract [eng] Triazole derivatives constitute an important group of heterocyclic compounds have have been the subject of extensive study in the recent past. These compounds have shown a wide range of biological and pharmacological activities. In this work, new fused tricyclic 1-(3-nitrophenyl)-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]-benzodiazepines have been synthesized by the thermal cyclization of N'-(2,3-dihydro-1H-1,5-benzodiazepin-4-yl)-3- nitrobenzohydrazides. After screening ethanol, toluene and 1-butanol as solvents, butanol-1 was found to be the best choice for the cyclization reaction in order to obtain the highest yields of tricyclic derivatives. The chemical structures of the synthesized compounds were elucidated by the analysis of their IR, 1H- and 13C-NMR spectral data. For tentative rationalization of the reaction processes, the global and local reactivity indices of certain compounds, taking part in the reaction pathway, were assessed by means of quantum mechanical calculations using the conceptual density functional theory (DFT) approach. This work could be useful for the synthesis of new heterocyclic compounds bearing a fused triazole ring.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2015
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