Title |
Therapeutic plasma exchange in multiple sclerosis patients with abolished interferon-beta bioavailability / |
Authors |
Giedraitienė, Nataša ; Kaubrys, Gintaras Ferdinandas ; Kizlaitienė, Rasa ; Bagdonaitė, Loreta ; Griškevičius, Laimonas ; Valčeckienė, Vilma ; Stoškus, Mindaugas |
DOI |
10.12659/MSM.894119 |
Full Text |
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Is Part of |
Medical science monitor.. Warsaw : Medical Science International. 2015, vol. 21, p. 1512-1519.. ISSN 1643-3750. eISSN 1643-3750 |
Keywords [eng] |
Neutralizing Antibodies ; Interferon-beta ; Multiple Sclerosis ; Plasma Exchange |
Abstract [eng] |
BACKGROUND Neutralizing antibodies (NAb) to interferon-beta (IFN-β) are associated with reduced bioactivity and efficacy of IFN-β in multiple sclerosis (MS). The myxovirus resistance protein A (MxA) gene expression is one of the most appropriate markers of biological activity of exogenous IFN-β. We hypothesized that therapeutic plasma exchange (TPE) can restore the ability of IFN-β to induce the MxA mRNA expression and that maintenance plasmapheresis can sustain the bioavailability of IFN-β. MATERIAL AND METHODS Eligible patients underwent 4 primary separate plasma exchange sessions. After the induction TPE sessions, they were transferred to maintenance plasmapheresis. Bioactivity of IFN-β was expressed as in vivo MxA mRNA induction in whole blood using RT-qPCR. RESULTS Six patients with low IFN-β bioavailability detected by the MxA mRNA response were included. Four patients became biological responders after induction plasmapheresis. In 2 patients an increase of MxA mRNA expression was found, but the values persisted below the cut-off and the patients remained as "poor biological responders". The effect of maintenance plasmapheresis was transient: MxA mRNA expression values reverted to the baseline levels after 1-2 months. CONCLUSIONS Therapeutic plasma exchange is able to restore the bioavailability of IFN-β in the majority of studied patients, but the effect of TPE on the IFN-β bioavailability was transient. . |
Published |
Warsaw : Medical Science International |
Type |
Journal article |
Language |
English |
Publication date |
2015 |
CC license |
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