Title Therapeutic plasma exchange in multiple sclerosis patients with abolished interferon-beta bioavailability /
Authors Giedraitienė, Nataša ; Kaubrys, Gintaras Ferdinandas ; Kizlaitienė, Rasa ; Bagdonaitė, Loreta ; Griškevičius, Laimonas ; Valčeckienė, Vilma ; Stoškus, Mindaugas
DOI 10.12659/MSM.894119
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Is Part of Medical science monitor.. Warsaw : Medical Science International. 2015, vol. 21, p. 1512-1519.. ISSN 1643-3750. eISSN 1643-3750
Keywords [eng] Neutralizing Antibodies ; Interferon-beta ; Multiple Sclerosis ; Plasma Exchange
Abstract [eng] BACKGROUND Neutralizing antibodies (NAb) to interferon-beta (IFN-β) are associated with reduced bioactivity and efficacy of IFN-β in multiple sclerosis (MS). The myxovirus resistance protein A (MxA) gene expression is one of the most appropriate markers of biological activity of exogenous IFN-β. We hypothesized that therapeutic plasma exchange (TPE) can restore the ability of IFN-β to induce the MxA mRNA expression and that maintenance plasmapheresis can sustain the bioavailability of IFN-β. MATERIAL AND METHODS Eligible patients underwent 4 primary separate plasma exchange sessions. After the induction TPE sessions, they were transferred to maintenance plasmapheresis. Bioactivity of IFN-β was expressed as in vivo MxA mRNA induction in whole blood using RT-qPCR. RESULTS Six patients with low IFN-β bioavailability detected by the MxA mRNA response were included. Four patients became biological responders after induction plasmapheresis. In 2 patients an increase of MxA mRNA expression was found, but the values persisted below the cut-off and the patients remained as "poor biological responders". The effect of maintenance plasmapheresis was transient: MxA mRNA expression values reverted to the baseline levels after 1-2 months. CONCLUSIONS Therapeutic plasma exchange is able to restore the bioavailability of IFN-β in the majority of studied patients, but the effect of TPE on the IFN-β bioavailability was transient. .
Published Warsaw : Medical Science International
Type Journal article
Language English
Publication date 2015
CC license CC license description