| Authors |
Mosztbacher, Dóra ; Hanák, Lilla ; Farkas, Nelli ; Szentesi, Andrea ; Mikó, Alexandra ; Bajor, Judit ; Sarlós, Patrícia ; Czimmer, József ; Vincze, Áron ; Hegyi, Péter Jenő ; Erőss, Bálint ; Takács, Tamás ; Czakó, László ; Németh, Balázs Csaba ; Izbéki, Ferenc ; Halász, Adrienn ; Gajdán, László ; Hamvas, József ; Papp, Mária ; Földi, Ildikó ; Fehér, Krisztina Eszter ; Varga, Márta ; Csefkó, Klára ; Török, Imola ; Farkas, Hunor Pál ; Mickevičius, Artautas ; Maldonado, Elena Ramirez ; Sallinen, Ville ; Novák, János ; Ince, Ali Tüzün ; Galeev, Shamil ; Bod, Barnabás ; Sümegi, János ; Pencik, Petr ; Dubravcsik, Zsolt ; Illés, Dóra ; Gódi, Szilárd ; Kui, Balázs ; Márta, Katalin ; Pécsi, Dániel ; Varjú, Péter ; Szakács, Zsolt ; Darvasi, Erika ; Párniczky, Andrea ; Hegyi, Péter |
| Abstract [eng] |
BACKGROUND: Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP.
METHODS: AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7-2.19 mmol/l, 2.2-5.59 mmol/l, 5.6-11.29 mmol/l, 11.3-22.59 mmol/l, ≥22.6 mmol/l).
RESULTS: Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia was considered as a causative etiological factor (≥11.3 mmol/l); however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications and organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well.
CONCLUSION: Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP. |
