| Title |
Association between hair cortisol concentration and metabolic syndrome / |
| Authors |
Mazgelytė, Eglė ; Mažeikienė, Asta ; Burokienė, Neringa ; Matuzevičienė, Rėda ; Linkevičiūtė, Aušra ; Kučinskienė, Zita Aušrelė ; Karčiauskaitė, Dovilė |
| DOI |
10.1515/med-2021-0298 |
| Full Text |
|
| Is Part of |
Open medicine.. Warszawa : Walter de Gruyter Poland. 2021, vol. 16, p. 873-881.. eISSN 2391-5463 |
| Keywords [eng] |
cortisol ; metabolic syndrome ; psychosocial stress |
| Abstract [eng] |
Metabolic syndrome(MetS)is a highly preva-lent disorder defined as a cluster of cardiometabolic riskfactors including obesity, hyperglycemia, hypertension,and dyslipidemia. It is believed that excessive cortisolsecretion due to psychosocial stress-induced hypotha-lamic-pituitary-adrenal axis activation might be involvedin the pathogenesis of MetS. We sought to explore theassociation between MetS and psychosocial risk factors,as well as cortisol concentration measured in different bio-logical specimens including saliva, blood serum, and hairsamples. The study was conducted on a sample of 163young and middle-aged men who were divided into groupsaccording to the presence of MetS. Hair cortisol concentra-tion(HCC)was determined using high performance liquidchromatography with UV detection, while blood serum andsalivary cortisol levels were measured by enzyme-linkedimmunoassay. Lipid metabolism biomarkers were deter-mined using routine laboratory methods. Anthropometricand lifestyle characteristics, as well as self-reported psy-chosocial indicators, were also examined. Significantlyhigher HCC and lower social support level among partici-pants with MetS compared with individuals without MetSwere found. However, no significant differences in bloodserum and salivary cortisol levels were observed betweenmen with and without MetS. In conclusion, chronically elevated cortisol concentration might be a potential contri-buting factor to the development of MetS. |
| Published |
Warszawa : Walter de Gruyter Poland |
| Type |
Journal article |
| Language |
English |
| Publication date |
2021 |
| CC license |
|
