Title Minimal infiltrative disease identification in cryopreserved ovarian tissue of girls with cancer for future use: a systematic review /
Authors Grubliauskaitė, Monika ; van der Perk, M. E. Madeleine ; Bos, Annelies M. E ; Meijer, Annelot J. M ; Gudlevičienė, Živilė ; van den Heuvel-Eibrink, Marry M ; Rascon, Jelena
DOI 10.3390/cancers15174199
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Is Part of Cancers.. Basel : MDPI. 2023, vol. 15, iss. 17, art. no. 4199, p. [1-26].. eISSN 2072-6694
Keywords [eng] fertility restoration ; ovarian tissue ; cryopreservation ; cancer survivors ; pediatric patients ; minimal infiltrative disease ; minimally residual disease
Abstract [eng] Background: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovarian tissue. Methods: A broad search for peer-reviewed articles in the PubMed database was conducted in accordance with PRISMA guidelines up to March 2023. Search terms included ‘minimal residual disease’, ‘cryopreservation’, ‘ovarian’, ‘cancer’ and synonyms. Results: Out of 542 identified records, 17 were included. Ovarian tissues of at least 115 girls were evaluated and categorized as: hematological malignancies (n = 56; 48.7%), solid tumors (n = 42; 36.5%) and tumors of the central nervous system (n = 17; 14.8%). In ovarian tissue of 25 patients (21.7%), MID was detected using RT-qPCR, FISH or multicolor flow cytometry: 16 of them (64%) being ALL (IgH rearrangements with/without TRG, BCL-ABL1, EA2-PBX1, TEL-AML1 fusion transcripts), 3 (12%) Ewing sarcoma (EWS-FLI1 fusion transcript, EWSR1 rearrangements), 3 (12%) CML (BCR-ABL1 fusion transcript, FLT3) and 3 (12%) AML (leukemia-associated immunophenotypes, BCR-ABL1 fusion transcript) patients. Conclusion: While the majority of malignancies were found to have a low risk of containing malignant cells in ovarian tissue, further studies are needed to ensure safe implementation of future fertility restoration in clinical practice.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2023
CC license CC license description