| Title |
Cellular hibernation and immunoparalysis in the context of sepsis induced organ dysfunction / |
| Translation of Title |
Cellular Hibernation and Immunoparalysis in the Context of Sepsis Induced Organ Dysfunction. |
| Authors |
Wegener, Svea |
| Full Text |
|
| Pages |
31 |
| Keywords [eng] |
Sepsis, MODS, Cytokine Storm, Cellular Hibernation, Immunoparalysis, Immunotherapy |
| Abstract [eng] |
Sepsis remains the leading cause of death in the intensive care unit. The limited effectivity of current therapies suggests that more research targeting the complex pathophysiologic processes of sepsis is essential to establish a comprehensive treatment with significant outcome improvement. This thesis is aimed to describe the counterintuitive pathophysiology of sepsis while focusing on the immunologic course of sepsis, the effects of cytokine storm, the cellular hibernation response to stress and their implication in organ dysfunction, the state of immune cell paralysis and potential treatment options. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Master thesis |
| Language |
English |
| Publication date |
2022 |
