| Title |
Oxidative stress and its biomarkers in cardiovascular diseases / |
| Authors |
Valaitienė, Julija ; Laučytė-Cibulskienė, Agnė |
| DOI |
10.1007/s44200-024-00062-8 |
| Full Text |
|
| Is Part of |
Artery research.. London : BioMed Central Ltd. 2024, vol. 30, iss. 1, art. no. 18, p. [1-12].. ISSN 1872-9312. eISSN 1876-4401 |
| Keywords [eng] |
biomarkers ; cardiovascular diseases ; endothelial cell dysfunction ; inflammation ; oxidative stress ; reactive oxygen species |
| Abstract [eng] |
Background: Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body: Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availability, vasoconstriction, and the development of procoagulant and proinflammatory states in blood vessels. Conclusion: Improved knowledge of biomolecular processes triggered by oxidative stress has helped develop tools for assessing oxidative stress markers and applying them in clinical settings. Nevertheless, some research gaps should be filled, specifically by defining the most clinically relevant biomarkers for oxidative stress with high sensitivity and specificity for CVD. |
| Published |
London : BioMed Central Ltd |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
