| Title |
Žarnyno mikrobiotos ir aknės koreliacija: probiotikų kaip adjuvantinės terapijos nauda aknės gydyme |
| Translation of Title |
The correlation between gut microbiota and acne: benefits of probiotics as adjuvant therapy in the treatment of acne. |
| Authors |
Antanaitytė, Adelė ; Radavičiūtė, Ieva ; Karmazienė, Tatjana |
| DOI |
10.53453/ms.2025.5.7 |
| Full Text |
|
| Is Part of |
Medicinos mokslai = Journal of medical sciences.. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras. 2025, vol. 13, iss. 3, p. 74-83.. ISSN 2345-0592 |
| Keywords [eng] |
gut microbiota ; leaky gut ; acne ; dysbiosis ; gut–skin axis ; probiotics |
| Abstract [eng] |
Introduction. Acne vulgaris is a persistent inflammatory skin condition with multiple causes. The pathophysiology of acne is influenced by inflammation, excessive sebum production, abnormal keratinisation of the pilosebaceous follicles and colonisation by Cutibacterium acnes (C. acnes). Acne can also be influenced by a complex population of microorganisms that live in the human gut, known as the gut microbiota. Obejctive. To review scientific literature on the correlation between gut microbiota and acne and the benefits of probiotics in the treatment of acne. Methods. The search of scientific literature was conducted in „PubMed“ and „Google Scholar“ databases. 140 articles were found by using keywords „gut microbiota“, „acne“, „dysbiosis“, „gut–skin axis“, „probiotics“. After excluding publications that did not meet the criteria, 30 articles were reviewed. Results. There is a significant effect of the gut microbiota in acne development. The protective and riskenchanting bacterial species were identified. Protective bacteria contribute to the production of acetic, butyric, propionic acids, which have anti-inflammatory properties. Acne risk increasing bacteria enchance the inflammatory response, promote angiogenesis. Probiotics with lactic acid and bifidobacteria are beneficial treating acne, both when used alone and in combiantion with antibiotics. Conclusions. Human microbiota have a major role in the development of acne. Protective bacteria inhibit inflammation, suppress proliferation of pathogens and reduce intestinal permeability, while acne risk enhancing bacteria activate inflammation, cause intestinal dysbiosis and trigger immune response. Probiotics could be used as an adjuvant therapy due to their anti-inflammatory properties. |
| Published |
Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2025 |
| CC license |
|
